Region play – the second season – is highlighted by a county clash Friday night.
Unbeaten Indian Land, 5-0, visits Andrew Jackson as a county headliner.
Buford also opens region play as the Jackets venture to Pageland to battle the unbeaten Central Eagles.
Lancaster, hoping for a happy homecoming, caps a three-game home stretch with a visit from Blythewood, a Midlands Class AAAA foe and former region foe.
Indian Land High football coach Mike Mayer said the Warriors will hope to extend their win streak against a tough Andrew Jackson squad, 2-3.